Estefanía Perdomo, soprano, performed María in Estudiantes y alguaciles by Bretón (Festival de Zarzuela), Contessa in Le Nozze di Figaro, Veronique in Le Docteur Miracle, Blanche in Dialogues des Carmelites, and Donna Anna in Don Giovanni (De Nieuwe Opera Academie, The Hague).

She has sung Bachiana N. 5 by Villalobos (Residentie Orkest, The Hague and Brabant Orkest's Cello Ensemble, Eindhoven), Mahler's 4^th Symphony, Messiaen's  Poemes Pour Mi (Noord Nederlands Orkest, M.Tabachnik, conductor), Fidelia in Edgar by Puccini (Leeuwarden, New Philharmonic Orchestra), Micaela in Carmen (Stella Den Haag, Het Nationale Toneel), a Jewish Music Program (Ensemble Le Tendre Amour in Carpentras , France), and a concert - homage to Isaac Albéniz (Liceu Barcelona).

More recently Estefanía Perdomo has performed Donna Anna in Don Giovanni (Japan), a series concerts with music by Roel van Oosten and Beethoven (Residentie Orkest, The Hague), and Bellangère in Paul Dukas's Arianne et Barbe-Bleue (NPS, Concertgebouw, Amsterdam, The Netherlands).

Upcoming engagements include Beethoven's 9^th Symphony (Vigo), Albeniz' The Magic Opal (Madrid), Mimi in La Bohème (Japan), Blumenmädchen in Parsifal (Liceu Barcelona), and Roel van Oosten's Mare Liberum (Delft, The Netherlands, Hamburg, Germany), among others.

Estefanía Perdomo won the prize for the best Spanish music performance in the Acisclo Fernández Carriedo Singing Competition (2005) and the Second Prize at the María Orán Concours in Tenerife (March 2010).